After I noticed, that JOHN84 has the same issue like me, I thought that it might help to post my Systemcheck infos.

I have now SplendidCRM running on a dedicated server outside of the domain and still have the issue, but still the same machine (so maybe I have to reinstall windows again to be sure...).

Anyhow, it would be nice if we could find a solution for john84 and for me, because I think it will fix our both issue at the same time.

System

SugarCRM compatibility
SplendidCRM Build	2.1.3074.33397
Server Name	localhost
Machine Name	STIMPY
ApplicationPath	/SplendidCRM
rootURL	/SplendidCRM/
imageURL	/SplendidCRM/Include/images/
scriptURL	/SplendidCRM/Include/javascript/
chartURL	/SplendidCRM/Include/charts/
Splendid Provider	System.Data.SqlClient
Default Theme
Default Language
Windows Authentication	false
Is Mobile Device	no
Browser Name	IE
Browser Version	7.0
User-Agent	Mozilla/4.0 (compatible; MSIE 7.0; Windows NT 5.2; .NET CLR 1.1.4322; .NET CLR 2.0.50727; .NET CLR 3.0.04506.30; .NET CLR 3.0.04506.648; .NET CLR 3.0.4506.2152; .NET CLR 3.5.30729)
User-Address	127.0.0.1

User

AUTH_USER
USER_ID	00000000-0000-0000-0000-000000000000
FULL_NAME
USER_NAME
IS_ADMIN	No
PORTAL_ONLY	No
themeURL

User Preferences

USER_SETTINGS/CULTURE
USER_SETTINGS/THEME	Sugar
USER_SETTINGS/DATEFORMAT
USER_SETTINGS/TIMEFORMAT
USER_SETTINGS/TIMEZONE
USER_SETTINGS/CURRENCY
USER_SETTINGS/MAIL_FROMNAME
USER_SETTINGS/MAIL_FROMADDRESS

Culture Defaults

Name	en-US
DisplayName	English (United States)
ShortDatePattern	M/d/yyyy
ShortTimePattern	h:mm tt
CurrencySymbol	$
CurrencyGroupSeparator	,
CurrencyDecimalSeparator	.
NumberGroupSeparator	,
NumberDecimalSeparator	.

System Log

DATE_ENTERED	ERROR_TYPE	USER_NAME	FILE_NAME	METHOD	LINE_NUMBER	MESSAGE
10/7/2008 8:45:53 AM	Warning		C:/Web.net/SplendidCRM5/_code/SplendidInit.cs	Void InitApp()	260	Application restart. Version 2.1.3074.33397
10/7/2008 8:46:07 AM	Error		C:/Web.net/SplendidCRM5/_code/SplendidInit.cs	Void InitApp()	373	Timeout expired. The timeout period elapsed prior to completion of the operation or the server is not responding.
10/7/2008 8:46:07 AM	Warning		C:/Web.net/SplendidCRM5/Global.asax.cs	Void InitSchedulerManager()	45	The Scheduler Manager timer has been activated.
10/7/2008 8:46:07 AM	Error		C:/Web.net/SplendidCRM5/_code/SplendidCache.cs	System.Data.DataTable Languages(System.Web.HttpApplicationState)	1168	Timeout expired. The timeout period elapsed prior to completion of the operation or the server is not responding.
10/7/2008 8:46:07 AM	Error		C:/Web.net/SplendidCRM5/_code/SplendidInit.cs	Void InitSession()	862	Index and length must refer to a location within the string. Parameter name: length
10/7/2008 8:46:07 AM	Error		C:/Web.net/SplendidCRM5/_code/TimeZone.cs	SplendidCRM.TimeZone CreateTimeZone(System.Guid)	105	Could not load default timezone nor EST timezone BFA61AF7-26ED-4020-A0C1-39A15E4E9E0A. Eastern Standard Time will be extracted from the Windows Registry and used as the default.
10/7/2008 8:46:07 AM	Error		C:/Web.net/SplendidCRM5/_code/SplendidCache.cs	System.Data.DataTable DetailViewRelationships(System.String)	1680	Timeout expired. The timeout period elapsed prior to completion of the operation or the server is not responding.
10/7/2008 8:46:07 AM	Error		C:/Web.net/SplendidCRM5/_code/SplendidCache.cs	System.Data.DataTable DetailViewRelationships(System.String)	1680	Timeout expired. The timeout period elapsed prior to completion of the operation or the server is not responding.
10/7/2008 8:46:07 AM	Error		C:/Web.net/SplendidCRM5/_code/SplendidCache.cs	System.Data.DataTable DetailViewRelationships(System.String)	1680	Timeout expired. The timeout period elapsed prior to completion of the operation or the server is not responding.
10/7/2008 8:46:07 AM	Error		C:/Web.net/SplendidCRM5/_code/SplendidCache.cs	System.Data.DataTable Languages(System.Web.HttpApplicationState)	1168	Timeout expired. The timeout period elapsed prior to completion of the operation or the server is not responding.
10/7/2008 8:47:22 AM	Error		C:\Web.net\SplendidCRM5\_code\WorkflowUtils.cs	Void Process(System.Web.HttpApplicationState)	166	Timeout expired. The timeout period elapsed prior to completion of the operation or the server is not responding.
10/7/2008 8:47:22 AM	Error		C:\Web.net\SplendidCRM5\_code\SchedulerUtils.cs	Void OnTimer(System.Object)	524	Timeout expired. The timeout period elapsed prior to completion of the operation or the server is not responding.
10/7/2008 8:52:22 AM	Error		C:\Web.net\SplendidCRM5\_code\WorkflowUtils.cs	Void Process(System.Web.HttpApplicationState)	166	Timeout expired. The timeout period elapsed prior to completion of the operation or the server is not responding.
10/7/2008 8:52:22 AM	Error		C:\Web.net\SplendidCRM5\_code\SchedulerUtils.cs	Void OnTimer(System.Object)	524	Timeout expired. The timeout period elapsed prior to completion of the operation or the server is not responding.
10/7/2008 8:55:10 AM	Error		C:/Web.net/SplendidCRM5/_code/SplendidCache.cs	System.Data.DataTable Languages(System.Web.HttpApplicationState)	1168	Timeout expired. The timeout period elapsed prior to completion of the operation or the server is not responding.
10/7/2008 8:55:10 AM	Error		C:/Web.net/SplendidCRM5/_code/SplendidInit.cs	Void InitSession()	862	Index and length must refer to a location within the string. Parameter name: length

Best regards,

Alexk